Cell contraction
Wound healing is made up of 3 processes: the formation of the epithelium, the deposition of connective tissue and contraction. The contraction process could be mediated by specialized fibroblasts called myofibroblasts. Three-dimensional collagen gels have been widely used to study fibroblast contraction, integrin signaling, cell apoptosis, and cytoskeleton reorganization, which may appear more biologically relevant …