Mouse Metastasis-suppressor KiSS-1 ELISA Kit

ELISA (Enzyme Linked Immunosorbent Assay) is a widely used application for detecting and quantifying proteins and antigens from various samples. Target-specific ELISA kits are available from a variety of manufacturers and can help optimize your immunodetection experiments.
ELISA kits for the detection of kisspeptin, an alias of the metastasis suppressor KiSS-1, are listed. The human protein, encoded by the KISS1 gene, is 138 amino acid residues long and 14,705 daltons in mass. He is a member of the KISS1 family. This protein is reported to have a secreted cellular location. The gene is associated with hypogonadotropic hypogonadism 13 with or without anosmia. For this target protein, ELISA kits are available with the following species reactivities: human, mouse, and rat. This target may also be known as: KiSS-1 metastasis suppressor, kisspeptin-1, malignant melanoma metastasis suppressor, metastin, HH13 and KiSS-1.

 

KiSS-1: metastasis suppressor protein in malignant melanomas and some breast cancers. It can regulate events downstream of cell matrix adhesion, perhaps involving reorganization of the cytoskeleton. It generates a C-terminal amidated peptide, metastin, which functions as an endogenous ligand for the G-protein-coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key features of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium from the first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca (2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine / endocrine regulator in the fine tuning of trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The KiSS1 / GPR54 hypothalamic system is a fundamental factor in the central regulation of the gonadotropic axis at puberty and in adulthood. It belongs to the KISS1 family.

 

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Protein type: Cell adhesion; Secreted signal peptide; Secreted

Cell component: apical plasma membrane; cell soma; cytoplasm; cytosol; extracellular space; neuron projection

Molecular function: binding to the G protein-coupled receptor; binding to the kisspeptin receptor; protein bond

Biological process: elevation of the concentration of cytosolic calcium ions; elevation of the concentration of cytosolic calcium ions during G protein signaling, coupled to the second messenger IP3 (activator of phospholipase C); G protein-coupled receptor protein signaling pathway; generation of the rhythm of the ovulation cycle; negative regulation of cell migration; negative regulation of cell proliferation; positive regulation of growth hormone secretion; positive regulation of luteinizing hormone secretion; positive regulation of the MAPKKK cascade; positive regulation of synaptic transmission